Developmental biology

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.

Developmental biology

Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.

Developmental biology

Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP

Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Developmental biology

Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.

Developmental biology

Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D

Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.

Developmental biology

Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D

CHAMP, a novel cardiac-specific helicase regulated by MEF2C.

Developmental biology

Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN

Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.

Developmental biology

Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE

Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.

Developmental biology

Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.

Developmental biology

Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D

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