Steven Altschuler, PhD

Professor
Pharmaceutical Chemistry
+1 415 502-3196

Dr. Steven Altschuler is interested in discovering principles underlying cellular individuality, the emergence of collective cellular behaviors, and the evolution of drug resistance. Dr. Altschuler also applies high-throughput technology developed by his laboratory to diverse problems, including mapping paths of signal transduction and accelerating drug discovery. Prior to arriving at UCSF, Dr. Altschuler worked at UT Southwestern, Harvard, Rosetta Informatics, Microsoft, Princeton, and the Institute for Advanced Studies.

Publications: 

Searching for molecular hypoxia sensors among oxygen-dependent enzymes.

eLife

Li L, Shen S, Bickler P, Jacobson MP, Wu LF, Altschuler SJ

Small Molecule in situ Resin Capture - A Compound First Approach to Natural Product Discovery.

bioRxiv : the preprint server for biology

Bogdanov A, Salib MN, Chase AB, Hammerlindl H, Muskat MN, Luedtke S, Barbosa da Silva E, O'Donoghue AJ, Wu LF, Altschuler SJ, Molinski TF, Jensen PR

Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity.

Cell reports

Rinaldi C, Waters CS, Li Z, Kumbier K, Rao L, Nichols RJ, Jacobson MP, Wu LF, Altschuler SJ

Selection of Optimal Cell Lines for High-Content Phenotypic Screening.

ACS chemical biology

Heinrich L, Kumbier K, Li L, Altschuler SJ, Wu LF

Biallelic TET2 mutations confer sensitivity to 5'-azacitidine in acute myeloid leukemia.

JCI insight

St?lzel F, Fordham SE, Nandana D, Lin WY, Blair H, Elstob C, Bell HL, Mohr B, Ruhnke L, Kunadt D, Dill C, Allsop D, Piddock R, Soura EN, Park C, Fadly M, Rahman T, Alharbi A, Wobus M, Altmann H, R?llig C, Wagenf?hr L, Jones GL, Menne T, Jackson GH, Marr HJ, Fitzgibbon J, Onel K, Meggendorfer M, Robinson A, Bziuk Z, Bowes E, Heidenreich O, Haferlach T, Villar S, Ariceta B, Diaz RA, Altschuler SJ, Wu LF, Prosper F, Montesinos P, Martinez-Lopez J, Bornh?user M, Allan JM

Publisher Correction: Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.

Nature biotechnology

Bao F, Deng Y, Wan S, Shen SQ, Wang B, Dai Q, Altschuler SJ, Wu LF

Integrative spatial analysis of cell morphologies and transcriptional states with MUSE.

Nature biotechnology

Bao F, Deng Y, Wan S, Shen SQ, Wang B, Dai Q, Altschuler SJ, Wu LF

Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters.

Science advances

Sun X, Bieber JM, Hammerlindl H, Chalkley RJ, Li KH, Burlingame AL, Jacobson MP, Wu LF, Altschuler SJ

Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs.

Communications biology

Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, Altschuler SJ

Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition.

Developmental cell

Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, Klein OD, Wu LF, Altschuler SJ

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions.

Cell systems

Morinishi L, Kochanowski K, Levine RL, Wu LF, Altschuler SJ

Generation and Quantitative Imaging of Enteroid Monolayers.

Methods in molecular biology (Clifton, N.J.)

Sanman LE, Chen IW, Bieber JM, Thorne CA, Wu LF, Altschuler SJ

A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors.

Scientific data

Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF

Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

Neoplasia (New York, N.Y.)

Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW

Planar Enteroids Reveal an Autonomous WNT And BMP Circuit Controlling Intestinal Epithelial Growth and Organization.

The FASEB Journal

Curtis A. Thorne, Ina W. Chen, Laura E. Sanman, Melanie H. Cobb, Lani F. Wu, Steven J. Altschuler

Drug persistence - from antibiotics to cancer therapies.

Current opinion in systems biology

Kochanowski K, Morinishi L, Altschuler S, Wu L

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.

Developmental cell

Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ

Sampling strategies to capture single-cell heterogeneity.

Nature methods

Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ

Abstract 3950: A novel combination therapy targeting BCL6 and phospho-STAT3 defeats intratumor heterogeneity in a subset of non-small cell lung cancers.

Tumor Biology

Dhruba Deb, Satwik Rajaram, Jill E. Larsen, Patrick P. Dospoy, Rossella Marullo, Longshan Li, Kimberley Avila, Leandro Cerchietti, John D. Minna, Lani F. Wu, Steven J. Altschuler

Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non-Small Cell Lung Cancers.

Cancer research

Deb D, Rajaram S, Larsen JE, Dospoy PD, Marullo R, Li LS, Avila K, Xue F, Cerchietti L, Minna JD, Altschuler SJ, Wu LF

Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils.

Science signaling

Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH

Examining Crosstalk among Transforming Growth Factor ß, Bone Morphogenetic Protein, and Wnt Pathways.

The Journal of biological chemistry

Coster AD, Thorne CA, Wu LF, Altschuler SJ

PHOCOS: inferring multi-feature phenotypic crosstalk networks.

Bioinformatics (Oxford, England)

Deng Y, Altschuler SJ, Wu LF

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.

PLoS biology

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.

Nature communications

Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, Thurley K, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ

Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines.

Nature biotechnology

Kang J, Hsu CH, Wu Q, Liu S, Coster AD, Posner BA, Altschuler SJ, Wu LF

The Developmental Rules of Neural Superposition in Drosophila.

Cell

Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR

Homer3 regulates the establishment of neutrophil polarity.

Molecular biology of the cell

Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD

On comparing heterogeneity across biomarkers.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Steininger RJ, Rajaram S, Girard L, Minna JD, Wu LF, Altschuler SJ

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors.

Nature chemical biology

Thorne CA, Wichaidit C, Coster AD, Posner BA, Wu LF, Altschuler SJ

The evolution and development of neural superposition.

Journal of neurogenetics

Agi E, Langen M, Altschuler SJ, Wu LF, Zimmermann T, Hiesinger PR

A simple image correction method for high-throughput microscopy.

Nature methods

Coster AD, Wichaidit C, Rajaram S, Altschuler SJ, Wu LF

Rapid Analysis and Exploration of Fluorescence Microscopy Images.

Journal of Visualized Experiments

Benjamin Pavie, Satwik Rajaram, Austin Ouyang, Jason M. Altschuler, Robert J. Steininger III, Lani F. Wu, Steven J. Altschuler

Rapid analysis and exploration of fluorescence microscopy images.

Journal of visualized experiments : JoVE

Pavie B, Rajaram S, Ouyang A, Altschuler JM, Steininger RJ, Wu LF, Altschuler SJ

Identifying network motifs that buffer front-to-back signaling in polarized neutrophils.

Cell reports

Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ

Envisioning migration: mathematics in both experimental analysis and modeling of cell behavior.

Current opinion in cell biology

Zhang ER, Wu LF, Altschuler SJ

The Zoo of Solitons for Curve Shortening in Rn

Nonlinearity

Altschuler D.J., Altschuler S.J., Angenent S.B., Wu L.F.

The zoo of solitons for curve shortening in On the occasion of Richard Hamilton's nth birthday.

Nonlinearity

Dylan J Altschuler, Steven J Altschuler, Sigurd B Angenent, Lani F Wu

Abstract 5226: Understanding single cell variability in oncogene induced pathway aberration in lung cancer.

Molecular and cellular biology

Dhruba Deb, Satwik Rajaram, Jill Larsen, John Minna, Lani Wu, Steven Altschuler

PhenoRipper: software for rapidly profiling microscopy images.

Nature methods

Rajaram S, Pavie B, Wu LF, Altschuler SJ

SimuCell: a flexible framework for creating synthetic microscopy images.

Nature methods

Rajaram S, Pavie B, Hac NE, Altschuler SJ, Wu LF

Network crosstalk dynamically changes during neutrophil polarization.

Cell

Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF

Denial, acceptance, and loss of cell polarization for a stochastic model of positive feedback.

The FASEB Journal

Steven Altschuler, Sigurd Angenent, Sasha Jilkine, Lani Wu

Dynamic information flow during neutrophil polarization.

The FASEB Journal

Lani Wu, Chin-Jen Ku, Yanqin Wang, Orion Weiner, Steven Altschuler

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Cell

Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Cell

Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD

A density-dependent switch drives stochastic clustering and polarization of signaling molecules.

PLoS computational biology

Jilkine A, Angenent SB, Wu LF, Altschuler SJ

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities.

Molecular systems biology

Singh DK, Ku CJ, Wichaidit C, Steininger RJ, Wu LF, Altschuler SJ

ON IDENTIFYING INFORMATION FROM IMAGE-BASED SPATIAL POLARITY PHENOTYPES IN NEUTROPHILS.

Proceedings. IEEE International Symposium on Biomedical Imaging

Ku CJ, Wang Y, Pavie B, Altschuler SJ, Wu LF

Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes.

The Journal of cell biology

Loo LH, Lin HJ, Singh DK, Lyons KM, Altschuler SJ, Wu LF

An approach for extensibly profiling the molecular states of cellular subpopulations.

Nature methods

Loo LH, Lin HJ, Steininger RJ, Wang Y, Wu LF, Altschuler SJ

Only two ways to achieve perfection.

Cell

Artyukhin AB, Wu LF, Altschuler SJ

Characterizing heterogeneous cellular responses to perturbations.

Proceedings of the National Academy of Sciences of the United States of America

Slack MD, Martinez ED, Wu LF, Altschuler SJ

On the spontaneous emergence of cell polarity.

Nature

Altschuler SJ, Angenent SB, Wang Y, Wu LF

An actin-based wave generator organizes cell motility.

PLoS biology

Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW

Systems-level analyses identify extensive coupling among gene expression machines.

Molecular systems biology

Maciag K, Altschuler SJ, Slack MD, Krogan NJ, Emili A, Greenblatt JF, Maniatis T, Wu LF

Automated Multivariate Profiling of Drug Effects from Fluorescence Microscopy Images

IEEE International Symposium on Biomedical Imaging

Loo, L.H., Wu, L., Altschuler, S.J., 2006; 251-54.

Genome-scale identification of nucleosome positions in S. cerevisiae.

Science (New York, N.Y.)

Yuan GC, Liu YJ, Dion MF, Slack MD, Wu LF, Altschuler SJ, Rando OJ

Genomic characterization reveals a simple histone H4 acetylation code.

Proceedings of the National Academy of Sciences of the United States of America

Dion MF, Altschuler SJ, Wu LF, Rando OJ

Multidimensional drug profiling by automated microscopy.

Science (New York, N.Y.)

Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ

A panoramic view of yeast noncoding RNA processing.

Cell

Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR

Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.

Science (New York, N.Y.)

Wedlich-Soldner R, Altschuler S, Wu L, Li R

Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters.

Nature genetics

Wu LF, Hughes TR, Davierwala AP, Robinson MD, Stoughton R, Altschuler SJ

Experimental annotation of the human genome using microarray technology.

Nature

Shoemaker DD, Schadt EE, Armour CD, He YD, Garrett-Engele P, McDonagh PD, Loerch PM, Leonardson A, Lum PY, Cavet G, Wu LF, Altschuler SJ, Edwards S, King J, Tsang JS, Schimmack G, Schelter JM, Koch J, Ziman M, Marton MJ, Li B, Cundiff P, Ward T, Castle J, Krolewski M, Meyer MR, Mao M, Burchard J, Kidd MJ, Dai H, Phillips JW, Linsley PS, Stoughton R, Scherer S, Boguski MS

On deforming confoliations

Journal of Differential Geometry

Altschuler, S.J., Wu, L.F.

On deforming confoliations.

Journal of Differential Geometry

Steven J. Altschuler, Lani F. Wu

Proceedings of the ICSLP

Speech/Noise Separation Using Two Microphones and a VQ Model of Speech Signals

Acero, A., Altschuler S.J., Wu L.F.

Proceedings of the ICSR5

Generating Signal Processing Software

Altschuler, S.J., Kim, W.

Proceedings of the Section on Physical and Engineering Sciences

Clustering finite discrete markov chains

Ridgeway, G., Altschuler, S.J.

Mean curvature flow through singularities for surfaces of rotation.

The Journal of Geometric Analysis

Steven Altschuler, Sigurd B. Angenent, Yoshikazu Giga

A geometric heat flow for one-forms on three dimensional manifolds.

Illinois Journal of Mathematics

Steven J. Altschuler

A geometric heat flow for one-forms on three dimensional manifolds

Illinois Journal of Mathematics

Altschuler, S.J.

Mean curvature flow through singularities for surfaces of rotation

Journal of Geometric Analysis

Altschuler, S.J., Angenet, S., Giga, Y.

Shortening space curves and flow through singularities

Journal of Differential Geometry

Altschuler, S.J., Grayson, M.

Mean curvature flow through singularities for surfaces of rotation.

Hokkaido University Preprint Series in Mathematics

Steven Altschuler, Sigurd Angenent, Yoshikazu Giga

Singularities for the curve shortening flow for space curves

Journal of Differential Geometry

Altschuler, S.J.