Deepak Srivastava, MD

Professor
Pediatrics
[email protected]
+1 415 734-2716

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

Publications: 

A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.

Nature Cardiovascular Research

Arun Padmanabhan, T. Yvanka de Soysa, Angelo Pelonero, Valerie Sapp, Parisha P. Shah, Qiaohong Wang, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Tomohiro Nishino, Lin Ye, Rachel Yang, Ashley Karnay, Andrey Poleshko, Nikhita Bolar, Ricardo Linares-Saldana, Sanjeev S. Ranade, Michael Alexanian, Sarah U. Morton, Mohit Jain, Saptarsi M. Haldar, Deepak Srivastava, Rajan Jain

Human spinal interneurons repair the injured spinal cord through synaptic integration.

bioRxiv : the preprint server for biology

Zholudeva LV, Fortino T, Agrawal A, Vila OF, Williams M, McDevitt T, Lane MA, Srivastava D

Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetes.

Nature Cardiovascular Research

Tomohiro Nishino, Sanjeev S. Ranade, Angelo Pelonero, Benjamin J. van Soldt, Lin Ye, Michael Alexanian, Frances Koback, Yu Huang, Langley Grace Wallace, Nandhini Sadagopan, Adrienne Lam, Lyandysha V. Zholudeva, Feiya Li, Arun Padmanabhan, Reuben Thomas, Joke G. van Bemmel, Casey A. Gifford, Mauro W. Costa, Deepak Srivastava

The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.

Stem cell reports

Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, Srivastava D

Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus.

Circulation

Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon EC, Qureshi TN, Reid CA, Nettesheim ER, Xu E, Duclos Z, Mohamed TMA, Farshidfar F, Fejes A, Liu J, Jones S, Feathers C, Chung TW, Jing F, Prince WS, Lin J, Yu P, Srivastava D, Hoey T, Ivey KN, Lombardi LM

Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease.

Circulation. Genomic and precision medicine

Young Jang M, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb BD, Porter GA, Seidman CE, Seidman JG

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.

Development (Cambridge, England)

Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG

Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes.

Circulation. Genomic and precision medicine

Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, Amgalan D, Rosa Ma X, Pereira A, Tcheandjieu C, Seidman C, Seidman J, Tristani-Firouzi M, Chung W, Goldmuntz E, Srivastava D, Loos RJF, Chami N, Cordell H, Dre?en M, Mueller-Myhsok B, Lahm H, Krane M, Pollard KS, Engreitz JM, Gagliano Taliun SA, Gelb BD, Priest JR

Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.

International immunopharmacology

Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F, Olson EN, Srivastava D

Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.

bioRxiv : the preprint server for biology

Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Gonzalez Teran B, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D

Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.

Science translational medicine

Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS

Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.

Circulation

Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D

Cellular cross-talk in heart repair.

Science (New York, N.Y.)

Srivastava D

Anniversary reflections: ISSCR presidents on 20 years of progress.

Cell stem cell

Little M, Morrison SJ, Rossant J, Srivastava D, Daley GQ

Neither cardiac mitochondrial DNA variation nor copy number contribute to congenital heart disease risk.

American journal of human genetics

Willcox JAL, Geiger JT, Morton SU, McKean D, Quiat D, Gorham JM, Tai AC, DePalma S, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, Tristani-Firouzi M, Gelb B, Porter GA, Seidman JG, Seidman CE

Transcription factor protein interactomes reveal genetic determinants in heart disease.

Cell

Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D

Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.

Circulation

Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, El-Baz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA

Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation.

Nature genetics

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R

BRD4 orchestrates genome folding to promote neural crest differentiation.

Nature genetics

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R

Modeling Human Cardiac Chambers with Organoids.

The New England journal of medicine

Srivastava D

Ebstein's Anomaly: Review of Arrhythmia Types and Morphogenesis of the Anomaly.

JACC. Clinical electrophysiology

He BJ, Merriman AF, Cakulev I, Stambler BS, Srivastava D, Scheinman MM

A transcriptional switch governs fibroblast activation in heart disease.

Nature

Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D

Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease.

JAMA cardiology

Morton SU, Shimamura A, Newburger PE, Opotowsky AR, Quiat D, Pereira AC, Jin SC, Gurvitz M, Brueckner M, Chung WK, Shen Y, Bernstein D, Gelb BD, Giardini A, Goldmuntz E, Kim RW, Lifton RP, Porter GA, Srivastava D, Tristani-Firouzi M, Newburger JW, Seidman JG, Seidman CE

Mouse gastruloids take heart.

Nature reviews. Cardiology

Srivastava D, McDevitt TC

Mentorship in Science: Response to AlShebli et al., Nature Communications 2020.

Stem cell reports

Mummery C, Little M, Lin H, Clark A, Zaret K, Srivastava D, Fuchs E, Watt F, Temple S

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

Science (New York, N.Y.)

Theodoris CV, Zhou P, Liu L, Zhang Y, Nishino T, Huang Y, Kostina A, Ranade SS, Gifford CA, Uspenskiy V, Malaschicheva A, Ding S, Srivastava D

BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.

Circulation

Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D

GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm.

eLife

Sharma A, Wasson LK, Willcox JA, Morton SU, Gorham JM, DeLaughter DM, Neyazi M, Schmid M, Agarwal R, Jang MY, Toepfer CN, Ward T, Kim Y, Pereira AC, DePalma SR, Tai A, Kim S, Conner D, Bernstein D, Gelb BD, Chung WK, Goldmuntz E, Porter G, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE

De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease.

Circulation. Genomic and precision medicine

Boskovski MT, Homsy J, Nathan M, Sleeper LA, Morton S, Manheimer KB, Tai A, Gorham J, Lewis M, Swartz M, Alfieris GM, Bacha EA, Karimi M, Meyer D, Nguyen K, Bernstein D, Romano-Adesman A, Porter GA, Goldmuntz E, Chung WK, Srivastava D, Kaltman JR, Tristani-Firouzi M, Lifton R, Roberts AE, Gaynor JW, Gelb BD, Kim R, Seidman JG, Brueckner M, Mayer JE, Newburger JW, Seidman CE

Genomic analyses implicate noncoding de novo variants in congenital heart disease.

Nature genetics

Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman JR, Newburger JW, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter GA, Bernstein D, Chung WK, Srivastava D, Tristani-Firouzi M, Troyanskaya OG, Dickel DE, Shen Y, Seidman JG, Seidman CE, Gelb BD

EM-mosaic detects mosaic point mutations that contribute to congenital heart disease.

Genome medicine

Hsieh A, Morton SU, Willcox JAL, Gorham JM, Tai AC, Qi H, DePalma S, McKean D, Griffin E, Manheimer KB, Bernstein D, Kim RW, Newburger JW, Porter GA, Srivastava D, Tristani-Firouzi M, Brueckner M, Lifton RP, Goldmuntz E, Gelb BD, Chung WK, Seidman CE, Seidman JG, Shen Y

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circulation research

Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.

Nature

de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

Cell stem cell

Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D

Oligogenic inheritance of a human heart disease involving a genetic modifier.

Science (New York, N.Y.)

Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D

Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.

Frontiers in physiology

Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Cell

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ

Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors.

Human mutation

Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, Boskovski MT, Parfenov M, Goldmuntz E, Chung WK, Brueckner M, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Gelb BD, Sharp AJ

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.

Cell

Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

Nature genetics

Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, Mital S, Russell MW, Gaynor JW, Deanfield J, Giardini A, Porter GA, Srivastava D, Lo CW, Shen Y, Watkins WS, Yandell M, Yost HJ, Tristani-Firouzi M, Newburger JW, Roberts AE, Kim R, Zhao H, Kaltman JR, Goldmuntz E, Chung WK, Seidman JG, Gelb BD, Seidman CE, Lifton RP, Brueckner M

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

JCI insight

Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.

Science translational medicine

Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.

Circulation research

Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL

Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.

The Journal of clinical investigation

Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

Journal of Cell Science

Jun-yi Zhu, Amy Heidersbach, Irfan S. Kathiriya, Bayardo I. Garay, Kathryn N. Ivey, Deepak Srivastava, Zhe Han, Isabelle N. King

The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.

Development (Cambridge, England)

Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.

Cell

Ang YS, Rivas RN, Ribeiro AJS, Srivas R, Rivera J, Stone NR, Pratt K, Mohamed TMA, Fu JD, Spencer CI, Tippens ND, Li M, Narasimha A, Radzinsky E, Moon-Grady AJ, Yu H, Pruitt BL, Snyder MP, Srivastava D

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.

Circulation

Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

Nature medicine

Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y

Effect of biophysical cues on reprogramming to cardiomyocytes.

Biomaterials

Sia J, Yu P, Srivastava D, Li S

Molecular Regulation of Cardiogenesis.

Epstein\u0027s Inborn Errors of Development

Deepak Srivastava, Joseph T. C. Shieh

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Trends in molecular medicine

Haldar SM, Srivastava D

Conversion of human fibroblasts into functional cardiomyocytes by small molecules.

Science (New York, N.Y.)

Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Scientific reports

Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR

Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.

Cell stem cell

Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S

A Tuned Tension Regulates the Contractility of Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells.

Biophysical journal

Alexandre J. Ribeiro, Yen-Sin Ang, Robin E. Wilson, Renee N. Rivas, Deepak Srivastava, Beth L. Pruitt

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.

Current protocols in human genetics

Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA

Heart disease modelling adds a Notch to its belt.

Nature cell biology

Gifford CA, Srivastava D

Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine.

Etiology and Morphogenesis of Congenital Heart Disease

Deepak Srivastava

Recent advances in direct cardiac reprogramming.

Current opinion in genetics & development

Srivastava D, Yu P

Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells.

Current protocols in human genetics

Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness.

Proceedings of the National Academy of Sciences of the United States of America

Ribeiro AJ, Ang YS, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL

microRNAs as Developmental Regulators.

Cold Spring Harbor perspectives in biology

Ivey KN, Srivastava D

NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.

Journal of molecular and cellular cardiology

White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D

Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses.

PloS one

Rasmussen TL, Ma Y, Park CY, Harriss J, Pierce SA, Dekker JD, Valenzuela N, Srivastava D, Schwartz RJ, Stewart MD, Tucker HO

Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.

Cell

Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D

Perfusion CT: can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis?

Abdominal imaging

Yadav AK, Sharma R, Kandasamy D, Bhalla AS, Gamanagatti S, Srivastava DN, Upadhyay AD, Garg PK

RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.

Circulation research

Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D

Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine.

Circulation journal : official journal of the Japanese Circulation Society

Fu JD, Srivastava D

Oxygen: double-edged sword in cardiac function and repair.

Circulation research

Ang YS, Srivastava D

Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia.

Human molecular genetics

Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H

Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.

Developmental biology

Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL

A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data.

Nature biotechnology

Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV, Wu W, Scheet P, Wang S, Xing J, Glusman G, Hubley R, Li H, Garg V, Moore B, Hood L, Galas DJ, Srivastava D, Reese MG, Jorde LB, Yandell M, Huff CD

The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.

The Journal of biological chemistry

King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN

Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.

Cell reports

Wang H, Cao N, Spencer CI, Nie B, Ma T, Xu T, Zhang Y, Wang X, Srivastava D, Ding S

Congenital heart disease: entering a new era of human genetics.

Circulation research

Bruneau BG, Srivastava D

microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.

eLife

Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D

The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.

Cell stem cell

Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S

Cardiac reprogramming: from mouse toward man.

Current opinion in genetics & development

Srivastava D, Berry EC

Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.

Stem cell reports

Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D

Fibronectin mediates mesendodermal cell fate decisions.

Development (Cambridge, England)

Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D

Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro.

Nature protocols

Qian L, Berry EC, Fu JD, Ieda M, Srivastava D

Small solutions to big problems: microRNAs for cardiac regeneration.

Circulation research

Srivastava D, Heidersbach AJ

AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy.

PloS one

Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR

Fending for a Braveheart.

The EMBO journal

Srivastava D, Cordes Metzler KR

Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells.

Stem cells translational medicine

Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I

Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.

Stem cells (Dayton, Ohio)

White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D

Stem cells in the land of the rising sun: ISSCR 2012.

Cell stem cell

Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein AR

A role for RNA post-transcriptional regulation in satellite cell activation.

Skeletal muscle

Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison D, Olwin BB

Cardiac repair with thymosin ß4 and cardiac reprogramming factors.

Annals of the New York Academy of Sciences

Srivastava D, Ieda M, Fu J, Qian L

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.

Cell

Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG

MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.

Circulation research

Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D

Social, communication, and cortical structural impairments in Epac2-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P

Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.

Cell stem cell

Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S

Critical factors for cardiac reprogramming.

Circulation research

Srivastava D, Ieda M

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.

Nature

Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D

Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.

PLoS genetics

Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V

A resource for the conditional ablation of microRNAs in the mouse.

Cell reports

Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT

Genetics of human cardiovascular disease.

Cell

Kathiresan S, Srivastava D

Tbx1 regulates oral epithelial adhesion and palatal development.

Human molecular genetics

Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H

Stem cell therapy for cardiac disease.

Pediatric research

Bernstein HS, Srivastava D

Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, Eds. Moss and Adams' Heart Disease in Infants, Children and Adolescents

Molecular determinants of cardiac development and disease

Baldwin HS
Srivastava D

Chromosomal haplotypes by genetic phasing of human families.

American journal of human genetics

Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF

Notch post-translationally regulates ß-catenin protein in stem and progenitor cells.

Nature cell biology

Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D

Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.

The Journal of cell biology

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R

Elevated miR-499 levels blunt the cardiac stress response.

PloS one

Shieh JT, Huang Y, Gilmore J, Srivastava D

A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity.

Developmental cell

King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D

A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.

Development (Cambridge, England)

Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes.

The Journal of experimental medicine

Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D

The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.

Science (New York, N.Y.)

Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.

Developmental dynamics : an official publication of the American Association of Anatomists

Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D

<i>Rudplph's Pediatrics</i> (Rudolph C, Rudolph A, Lister G, First L, Gershon A, Eds)

Control of embryologic cardiac development

Srivastava D

Hand2 function in second heart field progenitors is essential for cardiogenesis.

Developmental biology

Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D

The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch.

Development (Cambridge, England)

Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.

Proceedings of the National Academy of Sciences of the United States of America

Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D

Identification of GATA6 sequence variants in patients with congenital heart defects.

Pediatric research

Maitra M, Koenig SN, Srivastava D, Garg V

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.

Cell

Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D

A novel Slit–Robo–miR-218 signaling axis regulates VEGF-mediated heart tube formation in zebrafish.

Developmental biology

Stephanie Woo, Jason E. Fish, Joshua D. Wythe, Benoit B. Bruneau, Didier Y. Stainier, Deepak Srivastava

Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.

The Journal of heart valve disease

Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA

Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.

Journal of Biological Chemistry

Jason E. Fish, Matthew S. Yan, Charles C. Matouk, Rosanne St. Bernard, J. J. David Ho, Anna Gavryushova, Deepak Srivastava, Philip A. Marsden

Thymosin beta4 and cardiac repair.

Annals of the New York Academy of Sciences

Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I

Monkeying around with cardiac progenitors: hope for the future.

The Journal of clinical investigation

Qian L, Srivastava D

MicroRNAs in cardiac development.

Pediatric cardiology

Cordes KR, Srivastava D, Ivey KN

Micrornas in bicuspid aortic valve: a comparison between stenosis and insufficiency aortic valve.

The Thoracic and Cardiovascular Surgeon

SA Mohamed, V Nigam, B Jensen, H Sier, P Simpson, D Srivastava, HH Sievers

<i>Heart Development and Regeneration</i> (Rosenthal N, Harvey R, Eds)

MicroRNA regulation of cardiac development and disease

Cordes KR, Srivastava D

<i>Paediatric Cardiology</i> (Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, Eds)

The Aetiology of Congenital Cardiac Disease

Bruneau BG, Burn J, Srivastava D

CHAPTER 9 Aetiology of Congenital Cardiac Disease.

Paediatric Cardiology

Benoit G. Bruneau, John Burn, Deepak Srivastava

Chapter 10.3 MicroRNA Regulation of Cardiac Development and Disease.

Heart Development and Regeneration

Kimberly R. Cordes, Deepak Srivastava

Chapter 309 Signaling Pathways Involved in Cardiogenesis.

Handbook of Cell Signaling

Deepak Srivastava, Chulan Kwon

Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.

The Journal of biological chemistry

Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA

Notch1 represses osteogenic pathways in aortic valve cells.

Journal of molecular and cellular cardiology

Nigam V, Srivastava D

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.

Nature cell biology

Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.

Nature

Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D

Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo.

Journal of molecular and cellular cardiology

Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM

MicroRNA regulation of cardiovascular development.

Circulation research

Cordes KR, Srivastava D

Alternative induced pluripotent stem cell characterization criteria for in vitro applications.

Cell stem cell

Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL

Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.

Developmental cell

Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D

MicroRNAs: opening a new vein in angiogenesis research.

Science signaling

Fish JE, Srivastava D

<i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds)

Signaling pathways involved in cardiogenesis

Srivastava D, Kwon C

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.

Developmental biology

Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.

Proceedings of the National Academy of Sciences of the United States of America

Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ

microRNA-138 modulates cardiac patterning during embryonic development.

Proceedings of the National Academy of Sciences of the United States of America

Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D

A rare human sequence variant reveals myocardin autoinhibition.

The Journal of biological chemistry

Ransom JF, King IN, Garg V, Srivastava D

miR-126 regulates angiogenic signaling and vascular integrity.

Developmental cell

Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D

Transcriptional regulation during development of the ductus arteriosus.

Circulation research

Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D

Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction.

Circulation

Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D

MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.

Cell stem cell

Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D

<i>Inborn Errors of Development</i> (Epstein CJ, Ed)

Molecular regulation of cardiogenesis

Nigam V, Srivastava D

Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III.

Birth defects research. Part A, Clinical and molecular teratology

Gong B, Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ

Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5.

Proceedings of the National Academy of Sciences of the United States of America

Jia H, King IN, Chopra SS, Wan H, Ni TT, Jiang C, Guan X, Wells S, Srivastava D, Zhong TP

Thymosin beta4 is cardioprotective after myocardial infarction.

Annals of the New York Academy of Sciences

Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I

Spectrum of heart disease associated with murine and human GATA4 mutation.

Journal of molecular and cellular cardiology

Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.

Proceedings of the National Academy of Sciences of the United States of America

Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D

Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.

Proceedings of the National Academy of Sciences of the United States of America

Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN

Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.

American journal of medical genetics. Part A

Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.

Cell

Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D

A developmental view of microRNA function.

Trends in biochemical sciences

Zhao Y, Srivastava D

<i>Advances in Developmental Biology</i> (Bodmer R, Ed)

Role of microRNAs in Cardiovascular Biology

Samal E, Srivastava D

Role of microRNAs in Cardiovascular Biology.

Cardiovascular Development

Eva Samal, Deepak Srivastava

The genetics of cardiac birth defects.

Seminars in cell & developmental biology

Ransom J, Srivastava D

The paradoxical patent ductus arteriosus.

The Journal of clinical investigation

Ivey KN, Srivastava D

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition.

Circulation

Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.

Development (Cambridge, England)

Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L

Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa.

Biochemical and biophysical research communications

King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O

Sonic hedgehog is essential for first pharyngeal arch development.

Pediatric research

Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D

Tbx1 is regulated by forkhead proteins in the secondary heart field.

Developmental dynamics : an official publication of the American Association of Anatomists

Maeda J, Yamagishi H, McAnally J, Yamagishi C, Srivastava D

Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm.

Birth defects research. Part A, Clinical and molecular teratology

Gong B, Trent MB, Srivastava D, Boor PJ

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.

Nature genetics

Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG

MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling.

Proceedings of the National Academy of Sciences of the United States of America

Kwon C, Han Z, Olson EN, Srivastava D

The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

Cell

Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG

Mutations in NOTCH1 cause aortic valve disease.

Nature

Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.

Developmental biology

Aiyer AR, Honarpour N, Herz J, Srivastava D

<i>Principles of Molecular Cardiology</i> (Runge MS, Patterson C, Eds)

Genetic underpinnings of cardiogenesis and congenital heart disease

Garg V, Srivastava D

Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease.

Principles of Molecular Cardiology

Vidu Garg, Deepak Srivastava

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.

Development (Cambridge, England)

McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN

Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.

The Journal of biological chemistry

Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.

Developmental biology

Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M

<i>Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease</i> (Chien KR, Ed)

Cardiac Development and Congenital Heart Disease

Srivastava D, Olson EN

Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome.

Trends in molecular medicine

Yamagishi H, Srivastava D

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.

Nature

Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D

Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.

Developmental biology

Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM

Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryos.

Pediatric research

Yamagishi C, Hierck BP, Gittenberger-De Groot AC, Yamagishi H, Srivastava D

Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer.

Genes & development

Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D

<i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds)

Signaling pathways involved in cardiogenesis

Srivastava D

Building a heart: implications for congenital heart disease.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Srivastava D

Chapter 335 Signaling Pathways Involved in Cardiogenesis.

Handbook of Cell Signaling

Deepak Srivastava

Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene.

Genomics

Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH

Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis.

Cell and tissue research

Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.

Nature genetics

Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D

<i>Neonatal Cardiology</i> (Artman M, Mahony L, Teitel DF, Eds)

Molecular and morphogenetic cardiac embryology: Implications for congenital heart disease

Srivastava D

Molecular mechanisms of ventricular hypoplasia.

Cold Spring Harbor symposia on quantitative biology

Srivastava D, Gottlieb PD, Olson EN

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.

Developmental biology

Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D

A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L.

Mechanisms of development

Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D

Human eHAND, but not dHAND, is down-regulated in cardiomyopathies.

Journal of molecular and cellular cardiology

Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D

Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.

Developmental biology

Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D

CHAMP, a novel cardiac-specific helicase regulated by MEF2C.

Developmental biology

Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.

Proceedings of the National Academy of Sciences of the United States of America

Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.

Development (Cambridge, England)

McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN

Apoptosis during cardiovascular development.

Circulation research

Fisher SA, Langille BL, Srivastava D

A genetic blueprint for cardiac development.

Nature

Srivastava D, Olson EN

Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development.

Mechanisms of development

Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D

Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.

Development (Cambridge, England)

Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA

The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.

The Journal of clinical investigation

Yamagishi H, Olson EN, Srivastava D

<i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Clark EB, Nakazawa M, Takao A, Eds)

Role of the bHLH transcription factor, dHAND, in cranial/cardiac neural crest development

Yamagishi H, Srivastava D

<i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Takao A, Nakazawa M, Clark EB, Eds)

Understanding CHD through dissection of segmental cardiac molecular pathways

Srivastava D

DiGeorge syndrome: an enigma in mice and men.

Molecular medicine today

Srivastava D

Developmental and genetic aspects of congenital heart disease.

Current opinion in cardiology

Srivastava D

A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.

Science (New York, N.Y.)

Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D

<i>Heart Development</i> (Rosenthal N and Harvey R, Eds)

Segmental regulation of cardiac development by the basic helix-loop-helix transcription factors dHAND and eHAND

Srivastava D

A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme.

Development (Cambridge, England)

Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.

Developmental biology

Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.

Nature genetics

Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN

Knowing in your heart what's right.

Trends in cell biology

Srivastava D, Olson EN

Left, right ... which way to turn?

Nature genetics

Srivastava D

Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.

Nature genetics

Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN

<i>Genetic Control of Heart Development</i> (Harvey RP, Olson EN, Schulz RA, Altman JS, Eds)

The bHLH proteins, dHAND and eHAND in cardiac development

Srivastava D

A transcriptional pathway for cardiac development.

Cold Spring Harbor symposia on quantitative biology

Lin Q, Srivastava D, Olson EN

Neurotrophin-3 knocks heart off Trk.

Nature medicine

Srivastava D, Olson EN

Molecular pathways controlling heart development.

Science (New York, N.Y.)

Olson EN, Srivastava D

A subclass of bHLH proteins required for cardiac morphogenesis.

Science (New York, N.Y.)

Srivastava D, Cserjesi P, Olson EN

Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease.

Circulation

Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ